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Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

Study two In a 1997 study, 11 men aged 64-76 received nightly injections of 2mg sermorelin for six weeks

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The remainder is either digested by the gut microbiome or excreted in the feces of the infant

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