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Medically Reviewed Written by: Kia Michel, MD, Board-Certified Urologist, Urological Surgeon, & Sexual Health Specialist Reviewed by: Robert Sanford, MD, Board-Certified Urologist, Urological Surgeon, & Sexual Health Specialist Last Reviewed: March 02, 2026 12:50 pm PT How We Review Medical Content: Dr
Safety, tolerability and pharmacokinetics of PL 14736, a novel agent for treatment of ulcerative colitis, in healthy male volunteers
In one published case, an active, lean-adjacent man lost about one-third of his total weight as muscle on 2.5 mg and recovered it after adding resistance training and increasing protein. This is a cautionary case, not an incidence estimate