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Typical nasal research concentrations range from 100 to 250 mcg per spray

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When intestinal epithelial cells and immune cells detect bacterial components and metabolites through pattern recognition receptors (e.g., Toll-like receptors, TLRs), they activate NADPH oxidases, resulting in ROS production (O 2 - , H 2 O 2 )

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296 Therefore, PARPs have antiviral activity against multiple classes of viruses, including retroviruses, alphaviruses, filoviruses, herpesviruses, adenoviruses and coronavirus through enhancing the innate immunity