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In a clinical trial, DHA was not able to slow the progression of AD (Quinn et al., 2010), which could be due to oxidation of DHA ( Though we were supported by convincing data that sEH inhibitor TPPU ameliorates Alzheimers-like complications, TPPU should be further evaluated using Alzheimers disease-specific models

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In general, epoxy fatty acids produced from DHA, an -3 fatty acid are more potent anti-inflammatory agents than arachidonic acid (-6) derived EETs in several different bioassays