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The -glutamyl amino acid can be transported back into the cell where -glutamyl cyclo-transferase (GCT) releases the acceptor amino acid to form 5-oxo-proline, the latter of which is converted back to glutamate by oxo-prolinase and used for GSH synthesis

this decrease correlates with a diminished regenerative capacity of the organism

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Gong J, Hu X, Zhang J, Du Y, Huang R, Teng Y, Tan W, Shen L (2021) Phase Ia study of CBP-1008, a bi-specific ligand drug conjugate targeting FR and TRPV6, in patients with advanced solid tumors