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The use of scaffold-based 3D models to study ECs behavior and molecular mechanisms is also more frequent in cancer research, namely to investigate angiogenesis associated with tumorigenesis, and still very scarce for ECD investigation in the context of CVDs [245, 247]

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4.6 Overcoming challenges in translating natural compounds into clinical applications Despite promising findings, translating the therapeutic potential of natural compounds into clinical practice presents several key challenges

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