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The combination may reduce gut inflammation on multiple levels, including systemically, via cytokine signaling, and through modulation of the intestinal immune response

NICE guidelines for weight management emphasise evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, and in appropriate cases, pharmacological treatments (such as orlistat or semaglutide) or bariatric surgery

It may promote abnormal angiogenesis (new blood-vessel growth), raising theoretical concerns in patients with cancer history

Food and Drug Administration for any indication, off-label use among researchers and in experimental settings has grown, driven primarily by animal studies and anecdotal reports

This gap is especially pronounced for musculoskeletal end points such as tendon-to-bone healing and cartilage repair