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Conducting additional experiments with RPE cells donated by two people without AMD who did not smoke, one person without AMD who smoked and one person with early AMD, the researchers identified 1,698 genes that either increased or decreased in expression and were shared between dysfunctional human and mouse RPE cells

The prevalence of non-daily smoking was similar by occupational social grade among all adults but consistently higher among cigarette smokers from more advantaged compared with less advantaged social grades