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Notably, 4-HNE can activate the PPAR pathway, suppressing PGC-1-mediated mitochondrial biogenesis and reducing local ATP supply at synapses, thereby impairing plasticity mechanisms such as LTP (194)

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Consistent with these findings, in vitro zinc chelation has also been shown to decrease NK cell cytotoxicity, which could be increased through zinc supplementation [202]

Sulforaphane promotes neurogenesis in the subgranular and subventricular zone post-TBI, thereby aiding cognitive recovery (Thapa et al., 2021)

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