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Both are dominated by dose-related gastrointestinal effects (nausea, diarrhea, constipation)

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The same body weight, dose-response relationship cannot be assumed to hold true for older adults, and the risk of sarcopenia and reduced bone density with significant weight loss needs to be considered

A key characteristic of pyroptosis is the conversion of interleukin-1 (IL-1) and interleukin-18 (IL-18) via caspase 1 (Thornberry et al., 1992)