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The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial cellular proteins and nucleic acids

Boca Raton, FL, USA: CRC Press (2023)

Plant Physiol 142:13641379 Noshi M, Yamada H, Hatanaka R, Tanabe N, Tamoi M, Shigeoka S (2017) Arabidopsis dehydroascorbate reductase 1 and 2 modulate redox states of ascorbateglutathione cycle in the cytosol in response to photooxidative stress

Heme oxygenase-1 (HO-1) is an important source of intracellular iron that accelerates erastin-mediated ferroptotic cell death by provision of iron (Kwon et al., 2015)