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76,322,323,324 Therefore, mitochondrial targeting of NAMPT activity may be used to avoid the toxicity observed in first-generation inhibitors and provide an enhanced therapeutic window

On this occasion, the authors expand our understanding of glutathione biology and identify extracellular glutathione (GSH), abundant in the tumour microenvironment, as an alternative source of essential amino acids to sustain tumour cell proliferation

Th17 cell differentiation is also regulated by numerous cytokines

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