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Microbiome differences were greater between the two groups switched from WD to LD (i.e., WD/LD-V and WD/LD-T) and the two diet control groups (i.e., LD/LD-V and WD/WD-V) compared to the microbiome differences observed between the lean (LD/LD-V) and obese (WD/WD-V) control groups

1 2 3 4 Archives of Internal Medicine

For multi-dose vials used over weeks, bacteriostatic water is the standard because the benzyl alcohol preservative allows safe repeated draws without bacterial contamination risk

But the mechanism is well-characterized and the target (NNMT in adipose tissue) is a legitimate pathway for visceral fat reduction