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Irregularities in the numbers of Tregs and/or defects in their function can lead to autoimmune diseases ( in vivo study using a humanized mouse model of SLE, it was observed that CD19 CAR-Tregs delayed the onset of B cell lymphopenia, produced immunomodulatory cytokines, showed no toxicity or reprogramming towards Th17 pro-inflammatory cells, and furthermore, in the inflamed organs, restored the normal composition of the local immune site ( Neutrophils: Neutrophils are the primary cells of the innate immune system in peripheral blood circulation