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The non-management of chronic pain in the elderly can have large repercussions in terms of health and well-being with a high risk of depression, altered physical activity, higher outcomes of falls and malnutrition, and so an altered quality of life ( Reference Perrot 74 , Reference Ayres, Warmington and Reid 84 )
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Specifically, ZDHHC9-mediated palmitoylation of PD-L1 at Cys272 enhances its protein stability, which subsequently suppresses T cell activation and facilitates tumor immune escape
