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This situation occurs in chronic diseases such as hypertension, ischemic heart disease, and atherosclerosis 3,8,73

Consistent with this, analysis of multiple microarray datasets from the NCI-60 cell line panel (a panel of 60 diverse human cancer cell lines used by the National Cancer Institute for therapeutic development 12,13 ) demonstrated that SLC7A11 expression correlated more strongly with response to the APR-246 lead compound PRIMA-1 than any other gene (Supplementary Fig

77 Shahidi S et al

These cause the muscles in the blood vessels to relax, thereby lowering blood pressure and enhancement blood flow (161)

Doing so will help to tamp down oxidative stress in and of itself